Mar 12, 2009 a miniature cylindrical ion trap mass spectrometer is described, and preliminary data are presented. A miniature cylindrical ion trap mass spectrometer is described, and preliminary data are presented. A novel fourier transform ion trap mass spectrometer for. Range of stability for qms trajectories obeying mathieus equation. The present invention relates generally to an ion trap mass spectrometer for analyzing ions and more particularly to a substantially quadrupole ion trap mass spectrometer with an enlarged ion occupied volume. An ion trap mass spectrometer functions both as a mass spectrometer of considerable mass range and variable. With new lower prices, ion trap mass spectrometers are costeffective and. The popularity of the quadrupole ion trap has its roots in the discovery and development of the mass selective axial instability scan, for which g. Staffords discovery of the mass selective instability mode. Although mass spectrometers are widely used in this type of analysis, almost all such analyses are performed with largescale, high performance instruments. The integrated system features a low thermal mass capillary gas chromatograph with highspeed temperature programming and a miniaturized toroidal ion trap mass spectrometer tms with a mass range from 41 to 500 daltons. You can also say that for two ions of different mass but the same total kinetic energy, the heavier ion must move more slowly.
An ion trap mass spectrometer functions both as a mass spectrometer of considerable mass range and variable mass resolution and as an ion store in which gaseous ions can be confined. Obtain high sensitivity full scan ms along with indepth msn crm capabilities with the thermo scientific ltq xl linear ion trap mass spectrometer. With new lower prices, ion trap mass spectrometers are costeffective and provide automation features which enable all users, despite expertise level, to be more confident in not only their results, but instrument operation skills. Thermo scientific itq series gcms ion trap mass spectrometers mass spectrometer performance that meets your labs needs now and in the future itq series of ion trap mass spectrometers thermo. Historically, high pressure ion mobility drift tubes have suffered from low ion duty cycles and this problem is magnified when such instrumentation is coupled with ion trap mass spectrometers. Us5420425a ion trap mass spectrometer system and method. Two forms of mass spectrometers are derived from this idea, the omegatron and the fouriertransform spectrometer. Pdf in mass spectrometry separation of ions takes place on the basis of there mass to charge ratio. Wong bioanalytical systems west lafayette, in 4790682 r.
Capabilities include tandem mass spectrometry expts. The popularity of the quadrupole ion trap has its roots in the discovery and development of the massselective axial instability scan, for which g. A quadrupole ion trap ory of ion trap operation and give examples of. Product ion spectra at various precursor ion resolutions the increased resolution on product ion scan of alprazolam can selectively exclude ppg interferents with an actual mass difference of less than 0. We describe a prototype tandem mass spectrometer that is designed to increase the ef. They are also called radio frequency rf traps or paul traps in honor of wolfgang paul, who invented the device and shared the nobel prize in physics in 1989 for this work. March, an introduction to quadrupole ion trap mass spectrometry, journal of mass spectrometry 32, 3569 1997. The lcq fleet system leverages the proven reputation of the awardwinning lcq ion trap family for excellent ms n sensitivity, ruggedness and reliability. Analysis of glycopeptides using maldimini1 compact maldi.
It is possible to configure electric and magnetic fields so that ions can be held in stable orbits for a period of time long enough to perform useful measurements on them. Electrospray ion trap mass spectrometry introduction electrospray ion source the key to using ms for solutions is the ability to transfer your analytes into the vacuum of the mass spectrometer as ionic. Very sensitive realtime inline process mass spectrometer. Instrument development and first experimental results a. Continuing to set standards for rapid and reliable detection, the lcq fleet system is designed to meet. Imsitms ion mobility spectrometer ion trap mass spectrometer. The torion t9 gcms is the worlds smallest portable gcms, and is fast, reliable, and easy to use.
Principles of quadrupole and ion trap mass analyzers rev20040526. Gross massspectrometry atextbook with 357 illustrations and tables 123. Superior ion trap technology 2 from the leader in ion trap mass spectrometry, the ltq xl linear ion trap delivers ultimate sensitivity at breakthrough speed. Electrospray ion trap mass spectrometry introduction electrospray ion source the key to using ms for solutions is the ability to transfer your analytes into the vacuum of the mass spectrometer as ionic species. Quadrupole ion trap an overview sciencedirect topics.
With this data we may learn more about the time variations in the electrontoproton mass ratio. The high performance of quadrupole ion traps is illustrated by introducing some new. This paper compares the sensitivity and precision of ionratio measurements between a finnigan gcq iontrap mass spectrometer itms and a hewlett packard quadrupole mass. As the slope of the scan line drops the areas of stable ion trajectories begin to overlap more and more. A single quadrupole offers selected ion monitoring. To significantly alleviate these issues, we outline the result from coupling an atmospheric pressure, dualgate drift tube ion mobility spectrometer ims to a linear ion trap mass spectrometer litms. Linear quadrupole ion trap mass spectrometer quadrupole. Ion trap system overview 1 agilent 6300 series ion trap systems concepts guide 3 trap mass spectrometer the agilent 6300 series ion trap lcms consists of these components figure 2.
This paper compares the sensitivity and precision of ion ratio measurements between a finnigan gcq ion trap mass spectrometer itms and a hewlett packard quadrupole mass spectrometer qms using electron impact ionization with diazepam as the model compound. A twodimensional quadrupole ion trap mass spectrometer. Superior ion trap technology 2 from the leader in ion trap mass spectrometry, the ltq xl linear ion trap. Q1 set at unit resolution, spectrum is a composite of alprazolam and interfering ppg ions q1 set to pass only ppg ions. The smallest known quadrupole ion trap that has been evaluated for mass analysis or for isolation of ions of a narrow mass range was a hyperbolic trap with an r 0 value of 2. The theoretical basis for mass analysis using quadrupole fields is also described. Since the charge of an electron is known, the mass to charge ratio a measurement of an ion s mass. The next chapter describes the installation and operation of the chemical ionization source. Data system mass detector analyzer vacuum system source inlet region more precisely mass spectrometry determines the mass of a molecule. The design and operation of a linear quadrupole mass filter and a quadrupole ion trap mass spectrometer interfaced, in each case, with a membrane introductionfluid control system and. This configuration gives the linear ion trap a dual functionalityit can be used as a quadrupole mass filter or an ion trap. An orbitrap mass spectrometer consists of an inner spindlelike electrode and an outer barrellike. Functionality and performance of laboratoryscale instruments have been maintained to the. Mass spectrometry is an analytic method that employs ionization and mass analysis of compounds to determine the mass, formula and structure of the compound being analyzed.
Therefore it spends more time in the quadrupole and can see the field longer. Unlike other mass spectrometers that operate at pressures ion trap operates at 1 mtorr of helium. A novel highcapacity ion trapquadrupole tandem mass. Imsitms ion mobility spectrometer ion trap mass spectrometer fears of terrorism and the requirement to detect dangerous chemicals in low concentrations is leading to an everincreasing need, within homeland security, for reliable, realtime and sensitive detection of a wide range of substances that are a threat to.
This process is handled by an electrospray ion source in our instrument. Quadrupoles and ion traps hansjoachim huebschmann, thermo fisher scientific, singapore. Diy mass spectrometer measures potassium in dietary salt substitute duration. Very sensitive realtime inline process mass spectrometer based on fft ion trap technique hin yiu chung, michel aliman, gennady fedosenko, alexander laue, rudiger reuter, valerie derpmann. A linear ion trap uses a set of quadrupole rods coupled with electrodes on each end to facilitate the ion trapping. A mass analyzer is the component of the mass spectrometer that takes ionized masses and separates them based on charge to mass ratios and outputs them to the detector where. March, in encyclopedia of spectroscopy and spectrometry, 1999. Bioanalytical lcms 22 22 the mass peak in the quadrupole mass spectrum. In this thesis i describe the design of the electronics which will couple the ion trap to the. For a generalpurpose mass spectrometer look no further than the thermo scientific linear ion trap mass spectrometer. Mass analysis is performed by ejecting ions out a slot in one of the. Pdf a twodimensional quadrupole ion trap mass spectrometer.
The present invention relates generally to an ion trap mass spectrometer for analyzing ions and more particularly to a substantially quadrupole ion trap mass spectrometer with an enlarged ion occupied. Mass analysis is performed by ejecting ions out a slot in one of the rods using the mass selective instability mode of operation. This cost effective ion trap mass spectrometer delivers high quality structural information for routine analysis of complex samples, on a highthroughput basis. Described herein are electrode geometries that enlarge the ion occupied volume. Mass spectrometry mass spectrometry ion trap methods. A quadrupole ion trap is a type of ion trap that uses dynamic electric fields to trap charged particles. Miniature cylindrical ion trap mass spectrometer request pdf. The instrument is based on the ion path of a triple quadrupole mass spectrometer with q3 operable as either a conventional rfdc quadrupole mass filter or a linear ion trap mass spectrometer with axial ion ejection. Mass analyzers mass spectrometry chemistry libretexts. Profiling and characterization of polyphenol polymers from. The mass to charge ratio mz of the ion effects this motion. Principles of quadrupole and ion trap mass analyzers.
Pdf the quadrupole ion trap mass spectrometera small. Linear quadrupole ion trap mass spectrometer quadrupole ion. Augmenting ion trap mass spectrometers using a frequency. Scan speed vs cycle time on an ion trap mass spectrometer author. Instead, mass spectrometry is based upon the motion of a charged particle, called an ion, in an electric or magnetic field. One problem with this and other smallscale ion traps used in mass. An ion trap is a combination of electric or magnetic fields used to capture charged particles, often in a system isolated from an external environment. A mass spectrometer is an analytical instrument that can separate charged molecules according to their masstocharge ratio. Thermo scientific itq series gcms ion trap mass spectrometers mass spectrometer performance that meets your labs needs now and in the future itq series of ion trap mass spectrometers thermo scientific itq 700 gcms rugged performance for routine full scan applications combined with thermo scientific trace 0.
The quadrupole ion trap mass spectrometera small solution to a big challenge. Imsitms ion mobility spectrometer ion trap mass spectrometer fears of terrorism and the requirement to detect dangerous chemicals in low concentrations is leading to an everincreasing. This paper is a personal perspective of the commercial development of the threedimensional quadrupole ion trap mass spectrometer. The use of a linear or twodimensional 2d quadrupole ion trap as a high performance mass spectrometer is demonstrated. Q linear ion trap instrument to obtain product ion spectra is described. Electrospray ion trap mass spectrometry introduction. A quadrupole ion trap ory of ion trap operation and give examples of the pracis a mass analyzer roughly the size of a tennis ball tical application of ion trap mass spectrometry to. Ion traps have a number of scientific uses such as mass spectrometry, basic physics research, and controlling quantum states. One of the key advantages of ion trap mass spectrometry is the ability to perform multiple. Linear ion trap mass spectrometer part of thermo fisher scienti. One of the key advantages of ion trap mass spectrometry is the ability to perform multiple msms or msn fragmentation steps on a single precursor ion and its product ions to create a cascade of productprecursor ion relationships that yield extensiv e amounts of structural information. Borrmann1,2 1johannes gutenberguniversity mainz, germany 2max planck institute for chemistry, mainz, germany ion trap consists of.
The high performance of quadrupole ion traps is illustrated by introducing some new developments, including mass range extension, high resolution experiments, msn experiments, selective ion manipulation techniques. The qitms quadrupole ion trap mass spectrometer is an extraordinary instrument in that it is physically small the entire electrode assembly can be held in the palm of ones hand compared with. The quadrupole ion trap mass spectrometera small solution. Superior msn spectral quality and fullscan acquisition structural information on low level metabolites without knowing mrm transitions. The mass spectrometer can answer the questions what is in the sample. It is used as a component of a mass spectrometer or a trapped ion.
Graham cooks department of chemistry purdue university west lafayette, in 47907 corresponding author email. The integrated system features a low thermal mass capillary gas chromatograph with highspeed. Developing rapid quenching electronics for coupling an ion. There the particles masses may be precisely measured to determine if the vibrational transition was e ectively driven.
Thermo scientific itq series gcms ion trap mass spectrometers. Comparison of an iontrap and a quadrupole mass spectrometer. The third chapter contains ms maintenance procedures. The first chapter provides a functional description of the mass spectrometer ms and details of the instrument subsystems. When non mass spectrometrists are talking about mass spectrometry it rather often sounds as if they were telling a story out of poes tales of mystery and imagina. A novel fourier transform ion trap mass spectrometer for semiconductor processes 20181025 dr. Handheld miniature ion trap mass spectrometers analytical. View enhanced pdf access article on wiley online library html view download pdf. A triple quadrupole adds selected reaction monitoring.
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